Beilstein J. Org. Chem.2022,18, 1416–1423, doi:10.3762/bjoc.18.147
as an enantioselective catalyst for the asymmetric ring opening of terminal epoxides by phenols. A library of α-aryloxyalcohols 3 was thereafter synthesized in good yield and high ee using 2f via the phenolic KR of epichlorohydrin.
Keywords: α-aryloxyalcohols; chiral Co–salen; HKR
with regard to conformational differences, for instance, oligosalen [14], macrocyclic oligosalen [15], and polymeric salen [16].
Jacobsen and co-workers reported the first synthesis of α-aryloxyalcohols through the phenolic kinetic resolution (KR) of terminal epoxides using a Co–salen catalyst [17
synthesis of unsymmetrical salens for the preparation of Co–salen complexes and their evaluation as catalyst for the synthesis of α-aryloxyalcohols through the phenolic KR of terminal epoxides (Scheme 1). Indeed, advantages to break the C2-symmetry in Co–salen complexes were reported before [23][40]. In